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You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
Ketorolac tromethamine inhibits platelet function and is, therefore, CONTRAINDICATED in patients with suspected or confirmed cerebrovascular bleeding, patients with hemorrhagic diathesis, incomplete hemostasis, and those at high risk of bleeding (see WARNINGS and PRECAUTIONS).
Examples of affected drugs include lithium, pemetrexed, among others.
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In adults, following administration of single ORAL doses of Ketorolac tromethamine or IM or IV doses of Ketorolac tromethamine in the recommended dosage ranges, the clearance of the racemate does not change.
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Because patients with underlying renal insufficiency are at increased risk of developing acute renal decompensation or failure, the risks and benefits should be assessed prior to giving Ketorolac tromethamine to these patients.
Instruct that the duration of use should not exceed 5 days.
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In France, the country's health agency contraindicates the use of NSAIDs, including aspirin, after the sixth month of pregnancy.
Hypersensitivity to ketorolac; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to EDTA (intranasal only); active peptic ulcer disease; recent GI bleeding or perforation; history of peptic ulcer disease or GI bleeding; advanced renal impairment or in patients at risk of renal failure because of volume depletion; suspected or confirmed cerebrovascular bleeding; hemorrhagic diathesis, incomplete hemostasis, and patients at high risk of bleeding; as prophylactic analgesia before any major surgery and intra-operatively when hemostasis is critical; during the perioperative period in the setting of coronary artery bypass graft (CABG); for intrathecal or epidural administration (injection); during labor and delivery; breast-feeding; concomitant use with aspirin or other NSAIDs; concomitant use with probenecid or pentoxifylline.
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Based on our extensive literature review, this is the first documented systematic review of RCTs specifically evaluating ketorolac for prevention of acute pseudophakic CME.
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An additional aim of the study was to further evaluate the cardiovascular safety of rofecoxib.
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