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In France, the country's health agency contraindicates the use of NSAIDs, including aspirin, after the sixth month of pregnancy.

Hypersensitivity to ketorolac; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to EDTA (intranasal only); active peptic ulcer disease; recent GI bleeding or perforation; history of peptic ulcer disease or GI bleeding; advanced renal impairment or in patients at risk of renal failure because of volume depletion; suspected or confirmed cerebrovascular bleeding; hemorrhagic diathesis, incomplete hemostasis, and patients at high risk of bleeding; as prophylactic analgesia before any major surgery and intra-operatively when hemostasis is critical; during the perioperative period in the setting of coronary artery bypass graft (CABG); for intrathecal or epidural administration (injection); during labor and delivery; breast-feeding; concomitant use with aspirin or other NSAIDs; concomitant use with probenecid or pentoxifylline.

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Based on our extensive literature review, this is the first documented systematic review of RCTs specifically evaluating ketorolac for prevention of acute pseudophakic CME.

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