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Although the use of narcotics for severe RLS is controversial, some studies have suggested that even when the treatments are long-term, they are rarely addictive for pain sufferers except among patients with a history of substance abuse.
Accordingly, patients should be cautioned against rising rapidly after sitting or lying down, especially if they have been doing so for prolonged periods and especially at the initiation of treatment with MIRAPEX tablets.
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Areas in the brain that are responsible for the sensation of pain react differently in fibromyalgia patients than the same areas in healthy people.
Patients with restless legs syndrome (RLS) treated with pregabalin (Lyrica) had as much symptom improvement as those receiving pramipexole (Mirapex) in a large year-long trial, with fewer showing "augmentation.
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Throughout the trial, patients treated with MIRAPEX tablets had a mean of 4 "off" hours per day, while placebo-treated patients continued to experience 6 "off" hours per day.
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They may be more effective than SSRIs and SNRIs for fibromyalgia symptoms, although all three drug classes seem to show some effectiveness.
Use of high-dose prazosin may be more difficult in patients with baseline low BP and the dosing may have to be done more cautiously.
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Except for mild deficit in lexical fluency, STN or GPi DBS does not appear to adversely affect cognitive performance (), but some older patients have been found to have an impairment in frontal executive function ().
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Atropinisation (administration of a sufficient dose to block nerve gas effects) results in 100 percent blockade of the muscarinic acetylcholine receptors, and atropine sulphate is the benchmark for measuring the power of anticholinergic drugs.
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Decreased clearance following oral administration; however, dosage adjustment may not be necessary since dosage is titrated to adverse effect tolerability.
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