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ARAVA was statistically significantly superior to placebo in reducing the signs and symptoms of RA by the primary efficacy analysis, ACR20 Responder at Endpoint, in study Trial 1 (at the primary 12 months endpoint) and Trial 2 (at 6 month endpoint).
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It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.
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If evidence of bone marrow suppression occurs, discontinue drug and treat as indicated to reduce plasma concentration of leflunomide's active metabolite.
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This makes the prevalence difficult to define because the researchers were looking at a heterogeneous group of patients.
The risk increases the longer bisphosphonates are taken.
It is also is used to treat psoriatic arthritis, but the safety data has been largely borrowed from the rheumatoid arthritis studies.
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For some of these patients, it is not unreasonable that considerable risks associated with a drug such as leflunomide may be acceptable if there is sufficient benefit associated with the therapy.
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Leflunomide, or Arava, is another widely-used DMARD for RA with the potential for hair loss side effects.
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It has already held its first conference, at which Tony Blair was the keynote speaker.
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