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AstraZeneca submitted a for a version of quetiapine in the United States, Canada, and the European Union in the second half of 2006 for treatment of schizophrenia.

Background: As new biomarkers are identified, the traditional approach of comparing groups based on traditional clinical diagnostic categories may limit our understanding of the complex interaction between biology and behavior.

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Electroconvulsive therapy (ECT) may be considered for patients with severe mania or patients whose mania is treatment resistant, those patients who express a preference for ECT, and patients with severe mania during pregnancy.

Electroconvulsive therapy should not be prescribed as first line treatment or monotherapy in schizophrenia.

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If there is a history of autistic spectrum disorder or a communication disorder of childhood onset, the additional diagnosis of schizophrenia is made only if prominent delusions or hallucinations, in addition to the other required symptoms of schizophrenia, are also present for at least 1 month (or less if successfully treated).

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Note: WHO realizes that most of the world can't afford over-priced atypical antipsychotic medication.

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Importantly, mentalizing involves not only integrating social cues, but also contextual information, to build and adapt mental state inferences.

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FTD, 9 patients had no FTD, and two patients had mild FTD assessed with a clinical rating scale.

Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.

Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats".

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Methods: To distinguish among these possibilities, we used the following pre- and postsynaptic markers of dendritic spines: Vglut1, specific to excitatory terminals of cortical origin; spinophilin, protein phosphatase 1 binding protein that is highly concentrated in spines; PSD95 and gephyrin, scaffolding proteins for excitatory and inhibitory synapses, respectively.

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Methods: This is a multicenter cluster randomized controlled trial comparing CAT (intervention group) to Treatment As Usual (TAU, control group).

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Confirmatory factor analysis was used to assess the fit of the hypothesized two-factor structure of the API (decision-making autonomy and information-seeking autonomy); fit was evaluated using three common fit indices: the comparative fit index (CFI), the root mean square error of approximation (RMSEA), and the standardized root mean square residual (SRMR).

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MAFD4 is located at 16p12 and has been associated with susceptibility to bipolar disease in a cohort of 41 Finnish families.

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Exploratory analyses examined PP treatment response in patients with SCA early in their illness and those with a longer duration of illness.

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Background: The influence of antipsychotics on brain abnormalities and the characterization of predictive markers for treatment outcome are key questions in schizophrenia research.

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Conclusion: The characterization of this and other distinct circuitry effects of D2 antagonism and PDE10A inhibition has the potential to identify critical features of antipsychotic efficacy that will direct future efforts in this field.

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