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They have also found out I have fibrosis of my bone marrow and are unsure if it's caused by the medication or the CML.
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However, especially in non-aggressive disease (comprising the great majority of patients), at least partial improvement is usually attainable with one regimen or another, and thus the practitioner is obligated to persist with therapeutic trials until no options remain.
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III study of ponatinib compared with imatinib is just starting, and the same may prove to be true for ponatinib.
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Up to the data cutoff, nine patients died during the study.
Dasatinib substantially impaired both NK cell cytotoxicity and cytokine production even in IC 50 concentration (Figs.
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Nevertheless, Gorre and colleagues demonstrated that point mutations in BCR-ABL may be the primary mechanism of acquired resistance to imatinib, suggesting that the tyrosine kinase activity of BCR-ABL remains crucial in advanced disease.
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JMML leukemia cells is their spontaneous proliferation in vitro without the addition of exogenous stimuli, an ability that results from the leukemia cells being hypersensitive to GM-CSF.
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Click on citations within drug and disease topics in our clinical reference to review the clinical evidence on MEDLINE.
This gene encodes a protein containing a tyrosine kinase activity domain (SH1) in addition to two other regulatory domains (SH2 and SH3) that mediate protein-protein interaction and modulate activation of signal transduction.
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Además, la SG, la supervivencia sin enfermedad, la recidiva y la mortalidad sin recidiva fueron similares entre las dos cohortes.
The most common side effects seen with targeted therapies are and liver problems, such as and elevated liver enzymes.
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Moreover, the results provided herein represent the first mature clinical data to support the longer-term therapeutic promise of potent, intermittent kinase inhibition for the treatment of CML and other human malignancies.
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Most will see these side effects dissipate or go away completely over time.
The search space effectively restricts where the movable atoms, including those in the flexible side chains, should lie.
Because of this prognostic association, a reduction in the BCR-ABL transcript level by 3 log 10 units or more was defined as a major molecular response.
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