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Persons who received meningococcal polysaccharide vaccine (MPSV) 5 or more years previously and remain at increased risk for meningococcal disease should be revaccinated with MCV.

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IRIS in the cited study, 17 had culture-negative meningitis, and most cases occurred during the first 30 days after initiation of HAART.

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There are limited data on such an approach, with an unclear benefit in the context of the high pill burdens and significantly increased toxicity of such complex regimens.

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The VOICE participants who were most likely to adhere were similar, in terms of age and marital status, to women in the Partners PrEP trial.

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In patients with meningitis, CSF culture should be negative before initiation of consolidation therapy.

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In general, TAF was safe and when this formulation of tenofovir was substituted for TDF, improvements in bone density and kidney health were seen.

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Notably, using a very sensitive technique (ultra-deep pyrosequencing) viral variants with reduced sensitivity to lamivudine (substitutions in codons 204 and 181) were observed in four women (19%).

Guidelines and recommendations exist for dose adjustments necessary in adults treated with rifabutin and PIs, but the absence of data preclude extrapolating these to HIV-infected children being treated for TB.

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Although serious adverse events were not significantly different between treatment arms, there was increased nausea and vomiting in the zidovudine-containing arm, and increased diarrhea and rash in the stavudine-containing arm.

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In one long term study, the majority of increase in CD4 cell counts was in the first two years after starting ART with little increase afterwards.

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The addition of boceprevir nearly doubled the rate of anemia compared with the use of standard peginterferon and ribavirin therapy, with many patients requiring the use of erythropoietin.

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However, oocyst excretion can be intermittent; therefore, the parasite might not be detected in every stool, and among persons with milder disease, repeat stool sampling is recommended.

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