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In order to assess the efficacy and the long term safety of this drug, at week 12, 24 and 48 viral load, CD4 and safety parameters will be obtained.

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The presence of important concerns about one or more of these factors make a weak recommendation more likely.

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The purpose of this review was to assess which of these two medications was the best for initial treatment for people living with HIV, and through our search we identified two randomised controlled trials.

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Persons who received meningococcal polysaccharide vaccine (MPSV) 5 or more years previously and remain at increased risk for meningococcal disease should be revaccinated with MCV.

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Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity.

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IRIS in the cited study, 17 had culture-negative meningitis, and most cases occurred during the first 30 days after initiation of HAART.

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There are limited data on such an approach, with an unclear benefit in the context of the high pill burdens and significantly increased toxicity of such complex regimens.

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The VOICE participants who were most likely to adhere were similar, in terms of age and marital status, to women in the Partners PrEP trial.

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In patients with meningitis, CSF culture should be negative before initiation of consolidation therapy.

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In general, TAF was safe and when this formulation of tenofovir was substituted for TDF, improvements in bone density and kidney health were seen.

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Notably, using a very sensitive technique (ultra-deep pyrosequencing) viral variants with reduced sensitivity to lamivudine (substitutions in codons 204 and 181) were observed in four women (19%).

Guidelines and recommendations exist for dose adjustments necessary in adults treated with rifabutin and PIs, but the absence of data preclude extrapolating these to HIV-infected children being treated for TB.

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Although serious adverse events were not significantly different between treatment arms, there was increased nausea and vomiting in the zidovudine-containing arm, and increased diarrhea and rash in the stavudine-containing arm.

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In one long term study, the majority of increase in CD4 cell counts was in the first two years after starting ART with little increase afterwards.

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The addition of boceprevir nearly doubled the rate of anemia compared with the use of standard peginterferon and ribavirin therapy, with many patients requiring the use of erythropoietin.

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Cell culture studies have shown that both tenofovir and FTC can be fully phosphorylated when combined in cells.

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However, oocyst excretion can be intermittent; therefore, the parasite might not be detected in every stool, and among persons with milder disease, repeat stool sampling is recommended.

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This limits the likelihood of treatment failure, but is also beneficial for their own health and wellbeing, to prevent onward transmission by keeping their viral load down, and to help achieve UNAIDS 90-90-90 targets.

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Due to the presence of high HIV viral load levels, the probability of transmission when the source person is in the acute and early stage of HIV infection (first 6 months) has been shown to be 8- to almost 12-fold higher than exposures that take place after the viral set point.

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